Source: BEFREE

Variant Gene Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs28362491
rs28362491
CUI: C0019196
Disease: Hepatitis C
Hepatitis C
0.030 GeneticVariation BEFREE Besides normal routine laboratory testing for HCV, patients' sera were evaluated also for retinol, retinol-binding protein 4 and the following SNPs: PNPLA3 (rs738409), TM6SF2 (rs58542926), MBOAT7 (rs641738), IL28B (rs12979860), TIMP-1 (rs4898), TIMP-2 (rs8179090), NF-kB promoter (rs28362491). 31826071

2019

dbSNP: rs28362491
rs28362491
CUI: C0856825
Disease: Acute GVH disease
Acute GVH disease
0.010 GeneticVariation BEFREE We aim to analyze the association between NF-κB1 encoding p50 (rs28362491, -94 in.ertion/deletion ATTG) and miR-146a (rs2910164, G > C) polymorphisms and risk of aGVHD. 31813598

2019

dbSNP: rs28362491
rs28362491
CUI: C0220641
Disease: Lip and Oral Cavity Carcinoma
Lip and Oral Cavity Carcinoma
0.020 GeneticVariation BEFREE In subgroup analyses, the rs28362491 polymorphism was associated with the risk of nasopharyngeal carcinoma (NC), but not with oral cancer (OC). 31612070

2019

dbSNP: rs28362491
rs28362491
CUI: C0153381
Disease: Malignant neoplasm of mouth
Malignant neoplasm of mouth
0.020 GeneticVariation BEFREE In subgroup analyses, the rs28362491 polymorphism was associated with the risk of nasopharyngeal carcinoma (NC), but not with oral cancer (OC). 31612070

2019

dbSNP: rs28362491
rs28362491
CUI: C2931822
Disease: Nasopharyngeal carcinoma
Nasopharyngeal carcinoma
0.020 GeneticVariation BEFREE rs28362491 polymorphism was significantly associated with the risk of HNCs, especially with NC. 31612070

2019

dbSNP: rs28362491
rs28362491
CUI: C0278996
Disease: Malignant Head and Neck Neoplasm
Malignant Head and Neck Neoplasm
0.010 GeneticVariation BEFREE rs28362491 polymorphism was significantly associated with the risk of HNCs, especially with NC. 31612070

2019

dbSNP: rs28362491
rs28362491
CUI: C3887461
Disease: Head and Neck Carcinoma
Head and Neck Carcinoma
0.010 GeneticVariation BEFREE rs28362491 polymorphism was significantly associated with the risk of HNCs, especially with NC. 31612070

2019

dbSNP: rs28362491
rs28362491
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.020 GeneticVariation BEFREE Gene Combination of CD44 rs187116, CD133 rs2240688, NF-κB1 rs28362491 and GSTM1 Deletion as a Potential Biomarker in Risk Prediction of Breast Cancer in Lower Northern Thailand. 31450925

2019

dbSNP: rs28362491
rs28362491
CUI: C0006142
Disease: Malignant neoplasm of breast
Malignant neoplasm of breast
0.020 GeneticVariation BEFREE Gene Combination of CD44 rs187116, CD133 rs2240688, NF-κB1 rs28362491 and GSTM1 Deletion as a Potential Biomarker in Risk Prediction of Breast Cancer in Lower Northern Thailand. 31450925

2019

dbSNP: rs28362491
rs28362491
CUI: C0004364
Disease: Autoimmune Diseases
Autoimmune Diseases
0.010 GeneticVariation BEFREE Since interleukin-1 receptor-associated kinase (IRAK-1)/nuclear factor-kappa B (NF-kappa B) pathway plays an essential role in the pathogenesis of autoimmune diseases, the aim of the present study was to explore the role of polymorphisms in three genes, named IRAK1 (rs3027898), NFKBIA (rs696) and NFKB1 (-94ATTG insertion/deletion variant, - rs28362491), in PV susceptibility. 31077459

2019

dbSNP: rs28362491
rs28362491
CUI: C0030809
Disease: Pemphigus Vulgaris
Pemphigus Vulgaris
0.010 GeneticVariation BEFREE Association of NFKB1 -94ATTG ins/del polymorphism (rs28362491) with pemphigus vulgaris. 31077459

2019

dbSNP: rs28362491
rs28362491
CUI: C0742343
Disease: Acute Chest Syndrome
Acute Chest Syndrome
0.010 GeneticVariation BEFREE The aim of the present study was to explore the association between NFKB1 gene rs28362491 (-94ATTGins/del) polymorphism and ACS. 30910844

2019

dbSNP: rs28362491
rs28362491
CUI: C0948089
Disease: Acute Coronary Syndrome
Acute Coronary Syndrome
0.010 GeneticVariation BEFREE NFKB1 gene rs28362491 polymorphism is associated with the susceptibility of acute coronary syndrome. 30910844

2019

dbSNP: rs3774934
rs3774934
Respiratory Distress Syndrome, Adult
0.010 GeneticVariation BEFREE The IL-17 rs763780 and NF-κB1 rs3774934 SNPs had no impact on ARDS risk and prognosis of ARDS (<i>P</i>>0.05). 30655311

2019

dbSNP: rs28362491
rs28362491
CUI: C0019196
Disease: Hepatitis C
Hepatitis C
0.030 GeneticVariation BEFREE NFKB1 rs28362491-D allele was functionally associated with the increased risk of susceptibility to HCV infection in the Chinese Han population. 30056167

2018

dbSNP: rs3774937
rs3774937
CUI: C0006142
Disease: Malignant neoplasm of breast
Malignant neoplasm of breast
0.010 GeneticVariation BEFREE This is the first report that addresses the contribution of NF-κB variants to the pathogenesis of breast cancer in Middle Eastern-North African population, and the first to document positive association of rs3774937 with breast cancer. 30027470

2019

dbSNP: rs3774937
rs3774937
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.010 GeneticVariation BEFREE Histological type and grade, molecular type, Her2 positivity and ER+/Her2- correlated positively, while distant metastasis negatively correlated with rs3774937. 30027470

2019

dbSNP: rs3774937
rs3774937
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.010 GeneticVariation BEFREE This is the first report that addresses the contribution of NF-κB variants to the pathogenesis of breast cancer in Middle Eastern-North African population, and the first to document positive association of rs3774937 with breast cancer. 30027470

2019

dbSNP: rs1598859
rs1598859
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms
0.010 GeneticVariation BEFREE Insofar as altered NF-κB signaling stemming from the presence of specific genetic variants in NF-κB gene contribute to cancer pathogenesis, this study evaluated the association between NF-κB rs147574894/I552V, rs148626207/M860T rs3774937 and rs1598859 variants and breast cancer and associated features and complications. 30027470

2019

dbSNP: rs1598859
rs1598859
CUI: C1306459
Disease: Primary malignant neoplasm
Primary malignant neoplasm
0.010 GeneticVariation BEFREE Insofar as altered NF-κB signaling stemming from the presence of specific genetic variants in NF-κB gene contribute to cancer pathogenesis, this study evaluated the association between NF-κB rs147574894/I552V, rs148626207/M860T rs3774937 and rs1598859 variants and breast cancer and associated features and complications. 30027470

2019

dbSNP: rs1598859
rs1598859
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.010 GeneticVariation BEFREE Insofar as altered NF-κB signaling stemming from the presence of specific genetic variants in NF-κB gene contribute to cancer pathogenesis, this study evaluated the association between NF-κB rs147574894/I552V, rs148626207/M860T rs3774937 and rs1598859 variants and breast cancer and associated features and complications. 30027470

2019

dbSNP: rs1598859
rs1598859
CUI: C0006142
Disease: Malignant neoplasm of breast
Malignant neoplasm of breast
0.010 GeneticVariation BEFREE Insofar as altered NF-κB signaling stemming from the presence of specific genetic variants in NF-κB gene contribute to cancer pathogenesis, this study evaluated the association between NF-κB rs147574894/I552V, rs148626207/M860T rs3774937 and rs1598859 variants and breast cancer and associated features and complications. 30027470

2019

dbSNP: rs148626207
rs148626207
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.010 GeneticVariation BEFREE On the other hand, rs147574894 negatively correlated with histological type and grade, tumor size, Her2 positivity, molecular type, and ER+/Her2-, while rs148626207 correlated positively with histological grade, but negatively with distant metastasis and triple-negative status. 30027470

2019

dbSNP: rs147574894
rs147574894
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.010 GeneticVariation BEFREE On the other hand, rs147574894 negatively correlated with histological type and grade, tumor size, Her2 positivity, molecular type, and ER+/Her2-, while rs148626207 correlated positively with histological grade, but negatively with distant metastasis and triple-negative status. 30027470

2019

dbSNP: rs147574894
rs147574894
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.010 GeneticVariation BEFREE On the other hand, rs147574894 negatively correlated with histological type and grade, tumor size, Her2 positivity, molecular type, and ER+/Her2-, while rs148626207 correlated positively with histological grade, but negatively with distant metastasis and triple-negative status. 30027470

2019